EndoPAT is a safe, painless, non-invasive diagnostic device to access large and small arteries. It measures the endothelium (blood vessel lining) associated changes in vascular tone, pressure, and blood volume caused by a five-minute occlusion of the brachial artery using a blood pressure cuff and a finger probe. It is the only FDA cleared non-invasive test to evaluate endothelial function.

Endothelial dysfunction is the earliest detectable stage of cardiovascular disease, which includes heart attacks, stroke, and peripheral arterial disease. It is characterized by reduced nitric oxide (NO) availability. Nitric oxide plays a great role in maintaining vascular health and endothelium-dependent vasodilation. Patients with arginine deficiencies are more likely to suffer from low nitric oxide levels and endothelial dysfunction.

Endothelial dysfunction can lead to an inflammatory process that promotes the formation of atherosclerosis. It is involved in medical conditions such as erectile dysfunction, stroke, claudication, metabolic syndrome, pre-eclampsia toxemia, renal failure, sleep apnea, and other conditions associated with decreased vascular flow.