The treatment is minimally invasive with no downtime. A full-face treatment usually takes about an hour. Prior to the treatment, the face is numbed with a topical anesthetic cream for about 20 minutes. The face is then treated using the Dermapen micro-needling pen. The treatment makes tiny skin pinholes that leave the skin red and triggers the rejuvenation process. Patients can expect redness, itching, stinging, tightness, and swelling following a treatment that usually resolves within a few days. Microneedling can be combined with mesotherapy and sub-dermal blood injection to enhance results.